Pharmacokinetic parameters for midazolam and 1′-hydroxymidazolam after single intravenous administration of midazolam (0.25 mg/kg) in wild-type and Tg-CYP3A4 mice
| Parameters | Wild-Type | Tg-CYP3A4 | Tg-CYP3A4/Wild-Type |
|---|---|---|---|
| Midazolam | |||
| C max(nmol/l) | 593 ± 113 | 857 ± 335 | 1.45 |
| AUC0–180 min(nmol · min/l) | 6460 ± 601 | 8256 ± 842 | 1.28 |
| AUC0–∞(nmol · min/l) | 6530 ± 75 | 8390 ± 822 | 1.28 |
| V ss(liter) | 2.00 ± 0.30 | 1.80 ± 0.30 | 0.90 |
| CLiv(l/min) | 0.120 ± 0.00 | 0.10 ± 0.00 | 0.83 |
| MRT (min) | 17.0 ± 4.70 | 19.2 ± 1.70 | 1.13 |
| T 1/2(min) | 14.3 ± 2.60 | 20.8 ± 3.40 | 1.45 |
| 1′-OH-Midazolam | |||
| C max(nmol/l) | 135 ± 28.9 | 185 ± 49.6 | 1.37 |
| AUC0–180 min(nmol · min/l) | 4750 ± 367 | 9140 ± 1630 | 1.92 |
Values represent the mean ± S.D from three mice.