TABLE 1

AUC(15-45) values for thiopurine, thiopurine riboside, thiopurine nucleotide, and TX and TU in tissues after treatment of mice with 42.5 μmol/kg cis-AVTP, trans-AVTG, or 6-TG as described under Materials and Methods.

Values presented are the means ± S.D. from three-independent experiments.



Thiopurine

Thiopurine Riboside

Thiopurine Nucleotide

TX and TU

Plasma
RBC
Liver
Intestine
Plasma
RBC
Liver
Intestine
Plasma
RBC
Liver
Intestine
Plasma
RBC
Liver
Intestine
nmol min/ml or nmol min/g nmol min/ml or nmol min/g nmol min/ml or nmol min/g nmol min/ml or nmol min/g
cis-AVTP 38 ± 8* 28 ± 6 91 ± 26 110 ± 27 2 ± 1 N.D. 62 ± 16 20 ± 4* 6 ± 4 3 ± 0 142 ± 98 134 ± 6 114 ± 25* 28 ± 10 77 ± 13 360 ± 123*
trans-AVTG 17 ± 6 19 ± 8 52 ± 12 66 ± 18 1 ± 0 N.D. 111 ± 32 58 ± 15 8 ± 3 6 ± 3 191 ± 51 194 ± 51 17 ± 1 17 ± 3 N.D. 36 ± 10
6-TG
85 ± 9*
99 ± 34*
135 ± 2*
195 ± 30*
12 ± 3*
7 ± 4
312 ± 12*
146 ± 4*
4 ± 1
8 ± 0
208 ± 76
468 ± 49*
61 ± 13*
83 ± 21*
47 ± 11
150 ± 5*
  • N.D., not determined.

  • * Significantly different from trans-AVTG (P < 0.05)