Hepatic concentration of APAP and its metabolites in the bile duct-cannulated Wistar and TR- rats at the end of the experiment
Liver samples were collected at the end of the experiment and stored at -70°C before analysis by HPLC as described under Materials and Methods. The results are expressed as means ± S.E.M. for four animals per group.
Group | Concentrations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| APAP | APAP-GLU | APAP-SUL | APAP-GSH | APAP-CG/CYS | APAP-NAC | ||||||
| nmol/g liver | |||||||||||
| Wistar rats | 644 ± 158 | 512 ± 209 | N.D. | N.D. | N.D. | N.D. | |||||
| TR- rats | 366 ± 49* | 426 ± 28 | N.D. | 460 ± 205 | N.D. | 404 ± 274 | |||||
N.D., not detectable.
↵ * Significantly different (p < 0.05) from Wistar rats