Weak CYP3A inhibitors (oral midazolam used as probe substrate)
Drug | Dose/Regimen | Midazolam Dose | Fold Elevation in Midazolam AUC (GMR) | Reference |
|---|---|---|---|---|
| Grapefruit juice | 200 ml, normal strength, 1 h before | 15 mg p.o. | 1.5 | Kupferschmidt et al., 1995 |
| Roxithromycin | 300 mg q.d. × 6 days | 15 mg p.o. | 1.5 | Backman et al., 1994a (Versed package circular, 2001) |
|
Fentanyl
|
200 μg with nitrous oxide and isoflurane/(n = 15/group)
|
0.2 mg/kg p.o.
|
1.4
|
Hase et al., 1997
|