Cytochrome P450 concentrations in rat liver, relative liver weight, and voriconazole plasma concentrations after multiple (day 30) oral voriconazole administration
Dose (mg/kg) | Hepatic Microsomal Cytochrome P450 | Relative Liver Weight | Voriconazole Cmaxa | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Males | Females | Males | Females | Males | Females | ||||
| nmol P450/mg protein | μg/ml | ||||||||
| Control | 0.88 | 0.51 | 3.71 | 3.70 | —b | —b | |||
| 3 | 0.85 | 0.65 | 3.86 | 4.04 | 0.62 (0.21) | 1.32 (0.45) | |||
| 10 | 1.21 | 0.68 | 4.17 | 4.26 | 3.64 (1.24) | 6.14 (2.09) | |||
| 30 | 1.77 | 0.79 | 4.38 | 5.04 | 9.69 (3.29) | 14.6 (4.96) | |||
| 80 | 2.08 | 0.92 | 5.57 | 6.26 | 28.4 (9.66) | 30.4 (10.3) | |||