Enzymes implicated in drug biotransformation/clearance
Clearance Mechanism | Possible Enzymes/Proteins Involved |
|---|---|
| Oxidative metabolism | P450, FMO, MAO, Mo-CO, peroxidases |
| Hydrolytic metabolism | Esterases, amidases, epoxide hydrolases |
| Conjugative metabolism | UGT, ST, methyltransferase, acetyltransferase |
|
Excretion of unchanged drug
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Transporters
|