Examples of common positive controls and suggested concentrations for in vitro human P450 enzyme induction (LeCluyse et al., 2000; Meunier et al., 2000; Gerbal-Chaloin et al., 2001; Goodwin et al., 2001)
P450 | Inducer |
|---|---|
| CYP1A2 | Omeprazole (25 μM), β-naphthoflavone (10-50 μM) |
| CYP2B6 | Rifampicin (10-50 μM), phenobarbital (200-500 μM) |
| CYP2C9 | Rifampicin (10-50 μM), dexamethasone (10-50 μM) |
|
CYP3A4
|
Rifampicin (10-50 μM), dexamethasone (50 μM)
|