Drug-drug interactions due to the inhibition of transport proteins (modified from Ayrton and Morgan, 2001)
Substrate | Inhibitor | Effect | Potential Transport Protein |
|---|---|---|---|
| Digoxin | Quinidine, verapamil, itraconazole | ↑ Plasma concentrations, ↓ renal clearance | P-Glycoprotein; OATP |
| Fexofenadine | Ketoconazole, erythromycin, azithromycin | ↑ Plasma concentrations | P-Glycoprotein; OATP |
| Talinolol | Verapamil | ↑ or ↓ plasma concentrations; ↓ intestinal secretion | P-Glycoprotein |
| Loperamide | Quinidine | ↑ Central adverse events | P-Glycoprotein |
| Dofetilide, procainamide, levofloxacine | Cimetidine | ↑ in AUC; ↓ renal clearance | OCT; OAT; OATP |
| Penicillins, ACE inhibitors, antiviral drugs | Probenecid | ↓ Renal clearance; prolong t1/2 | OAT |
|
Paclitaxel
|
Valspodar
|
↑ Plasma concentrations
|
P-Glycoprotein
|
OCT, organic cation transporter; OAT, organic anion transporter; OATP, organic anion transport protein.