TABLE 2

Pharmacokinetic parameters of macrolides used in the simulation


Parameter

Value

Schedule or Source

Reference
Erythromycin
    Dose 681,200 (nmol) t.i.d. A, B
    Fa · Fg 0.58 Unpublished observation
    fb 0.16 H
    Kp 1 assumed
    Vliver 2,800 (ml)
    Vpv 70 (ml)
    Q 1,610 (ml/min)
    CLint 2,940 (ml/min) *
    ka 0.011 (min-1) *
    CLr 0 (ml/min) *
    Vsys 18,000 (ml) *
    Tlag 96 (min) I
Clarithromycin
    Dose 334,242, 668,485 (nmol) b.i.d. C, D
    Fa · Fg 1 *
    fb 0.28 calculated from fu = 0.18, Rb = 0.64 J, H
    Kp 1 assumed
    Vliver 2,800 (ml)
    Vpv 70 (ml)
    Q 1,610 (ml/min)
    CLint 2,176 (ml/min) *
    ka 0.018 (min-1) *
    CLr 100 (ml/min) *
    Vsys 100,000 (ml) *
    Tlag 12 (min) K
Azithromycin
    Dose 636,943 (nmol) o.d. B, C
    Fa · Fg 0.86 L
    fb 0.7 L
    Kp 1 assumed
    Vliver 2,800 (ml)
    Vpv 70 (ml)
    Q 1,610 (ml/min)
    CLint 1,800 (ml/min) *
    ka 0.00175 (min-1) *
    CLr 100 (ml/min) *
    Vsys
24,500 (ml)
*