TABLE 2

Possible AREs in the human CYP3A4 gene


Response Element Name (Location)

Putative CYP3A4 ARE

Reported ARE Elements in Other Genes
ARE-1 GGGACActtTGGATT GGAACAtatTGTATT
−6942 to − 6956 nt PSA Enhancer III
ARE-2 GGTTCAagcAGCCTC GGATCAgggAGTCTC
−6667 to −6681 nt PSA ARE-2
ARE-3 AGAACAtgtGGTTCT AGAACAgcaAGTGCT
−11135 to −11149 nt PSA ARE-1
ARE-4 AGGTCAtaaAGCCCA GGGACAtaaAGCCCA
−7777 to −7791 nt Probasin G-1
ARE-5 GGAACAtttTGCAAC GGGACAactTGCAAA

−9332 to −9346 nt
PAS Enhancer V
  • nt, nucleotide.