TABLE 4

Measured vs. literature K_m and V_max values.

Substrate/Enzyme	K_m			V_max			Reference
Substrate/Enzyme		Measured	Literature	Measured	Literature		Reference
	μM			nmol/min/nmol protein
Phenacetin 1A2		46		0.92	Rodrigues et al., 1997
		35		3	Lin et al., 2001
		35-95			Jensen et al., 1995
	25	31	1.4	2.4	Venkatakrishnan et al., 1998
		28		20	Kobayashi et al., 1999
		14-57			Brøsen et al., 1992
Diclofenac 2C9		8		15	Masimirembwa et al., 1999
		2		13	Yamazaki et al., 1998
		2.3			Crespi and Penman, 1997
	2	15	14		Mancy et al., 1999
					Tang et al., 1999
		1.4			Tang et al., 1999
		5.2		30	Tang et al., 1999
Mephenytoin 2C19		18		2.5	Lin et al., 2001
		35-49		6	Venkatakrishnan et al., 1998
	20	30	13		Yin et al., 2000
Bufuralol 2D6		11		16	Smith et al., 1998
		10			Crespi and Penman, 1997
	9	3.4	12		Mankowski, 1999
		15			Yin et al., 2000
Midazolam 3A4		6.4			Perloff et al., 2000
		4.2-6.1			Gascon and Dayer, 1991
	2.5	3.7	2.4		Wandel et al., 1998
		3-4			von Moltke et al., 1996
		2.4			Yin et al., 2000