Substrate  CYP3A4 Modifier  V_{max}  K_{s}  K_{i}  γ  δ 

pmol/min/pmol P450  μM  μM  
Nifedipine^{a}  MDZ  6.5±0.1  19.4±1.5  20.8±4.1  0.45±0.10  0.95±0.11 
FEL  10.1±0.2  36.3±1.7  16.6±3.7  0.56±0.09  0.62±0.09  
Felodipine  MDZ^{b}  13.8±0.5  46.2±4.3  198±41  0.81±0.11  0.22±0.04 

NIF^{c}

16.5±0.4

34.8±2.0

33.1±8.0


2.1±0.1

↵ a Equation 3, β (K_{p} from SES) = 0.41±0.10 (MDZ) and 0.44±0.09 (NIF)
↵ b Equation 2 (Galetin et al., 2002), β = 2 as V_{max} is equivalent to 2K_{p}[E]_{t}, where [E]_{t} is the total enzyme concentration (Segel, 1975)
↵ c Partial inhibition model defined by eq. 2 was applied