Cumulative urinary excretion of AA and AA metabolites after PB, DAS, OLT, or TSO pretreatment Experimental conditions are the same as those described for Fig. 1. Urine was collected over 90 min after administration of AA (1 mmol/kg i.v.). Values are means ± S.E.M.
AA-GLUC | AA-SULF | AA | AA-NACa | Total | |||||
|---|---|---|---|---|---|---|---|---|---|
| μmol/kg | |||||||||
| Control | 24.1±2.7 | 87.6±8.8 | 9.1±1.0 | 1.3±0.2 | 117±13.9 | ||||
| PB | 86.5±2.8* | 85.9±14.5 | 8.4±0.9 | 6.3±1.6* | 187±15.2 | ||||
| DAS | 95.3±14.3* | 78.2±11.8 | 9.2±1.4 | 5.3±1.0* | 189±26.4 | ||||
| OLT | 125.0±34.8* | 80.0±20.6 | 7.6±0.9 | 10.9±1.2* | 223±56.6* | ||||
|
TSO
|
181.9±32.6*
|
100.1±20.9
|
16.0±3.0
|
14.3±2.3*
|
312±58.0*
| ||||