Correlation of UGT2B7 protein content with glucuronidation activities Glucuronidation activities and immunoquantified UGT2B7 protein content were measured in the same set of human liver microsomes (n = 54) and compared by Spearman rank order correlation analysis. Values represent the Spearman correlation coefficient (rs), and P value for the indicated comparisons.
Activity | UGT2B7 Protein Content vs. | ||
|---|---|---|---|
|
Spearman Correlation (rs)
| P Value
| ||
| AZT glucuronidation | 0.765a | <0.001 | |
| Morphine-3-glucuronidation | 0.503a | <0.001 | |
| Morphine-6-glucuronidation | 0.509a | <0.001 | |
| Codeine glucuronidation | 0.33 | 0.015 | |
| Estradiol-3-glucuronidation | -0.254 | 0.0637 | |
| Trifluoperazine glucuronidation | 0.0646 | 0.641 | |
| Serotonin glucuronidation | -0.133 | 0.341 | |
| Propofol glucuronidation | -0.0613 | 0.658 | |
| R-Oxazepam glucuronidation | 0.424 | 0.0015 | |
| S-Oxazepam glucuronidation
|
0.351
|
0.00954
| |
↵ a Correlations were considered statistically significant when the rs value was greater than or equal to 0.50 and the P value was less than 0.001