Percentage of AA metabolite excreted into urine or bile after PB, DAS, OLT, or TSO pretreatment Experimental conditions are the same as those described for Fig. 1. Bile and urine were collected over 90 min after administration of AA (1 mmol/kg i.v.). Values are the percentage of the total amount of metabolite excreted into bile and urine over 90 min.
AA-GLUC | AA-SULF | AA-GSH + AA-Mercapturate | Total | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Bile
|
Urine
|
Bile
|
Urine
|
Bile
|
Urine
|
Bile
|
Urine
| |||||
| Control | 78 | 22 | 20 | 80 | 93 | 7 | 53 | 47 | ||||
| PB | 30 | 70 | 9 | 91 | 91 | 9 | 40 | 61 | ||||
| DAS | 15 | 85 | 8 | 92 | 68 | 32 | 20 | 80 | ||||
| OLT | 12 | 88 | 5 | 95 | 60 | 40 | 16 | 84 | ||||
|
TSO
|
9
|
91
|
6
|
94
|
30
|
70
|
10
|
90
| ||||