TABLE 2

Pharmacokinetic parameters of duloxetine and total radioactivity in subjects receiving an oral dose of [14C]duloxetine


Parameter

Arithmetic Mean (%CV)
Duloxetine (n = 4)
Radioactivity (n = 4)
Duloxetine/Radioactivity Ratio
%
T max a 6.0 6.0
(h) (4.0-16.0) (6.0-6.0)
C max 23.5 274 8.5
(ng/ml) (60) (6) (61)
AUC0-t 236 7774 2.8
(ng · h/ml) (71) (25) (52)
AUC0-∞ 257 8770 2.7
(ng · h/ml) (71) (25) (52)
t 1/2 b 10.3 120
(h) (6.75-13.6) (104-141)
CLp/F 119
(l/h) (68)
Vz/F 1787
(liters)
(71)


  • n = number of subjects included in means

  • a Median (range)

  • b Harmonic mean (range)