TABLE 3

Radiochromatographic HPLC peak area percentages of duloxetine and duloxetine metabolites in pooled plasma


Compound

Peak Area %
4 h
6 h
10 h
24 h
Glucuronide conjugate of 4-hydroxy duloxetine (M6) 49 42 47 56
Sulfate conjugate of 5-hydroxy-6-methoxy duloxetine (M7) 31 24 21 8
Glucuronide conjugate of 4, 6-dihydroxy duloxetine (M9) 5 18 14 7
Glucuronide conjugate of 6-hydroxy-5-methoxy duloxetine (M10) 12 12 13 12
Duloxetine
3
4
4
11