Percentage of total dose of duloxetine and its metabolites in feces
Compound | Percentage of Dosea | ||||||
|---|---|---|---|---|---|---|---|
|
Subject 1 72-96 h
|
Subject 2 72-96 h
|
Subject 3 48-72 h
|
Subject 4 48-72 h
| ||||
| Duloxetine | 0.2 | 0.1 | 4.1 | 3.4 | |||
| 4-Hydroxy duloxetine (M14) | 0.3 | 0.5 | 2.3 | 1.7 | |||
| Unknown metabolite(s) | 4.6 | 4.9 | 2.3 | 4.7 | |||
| Sum | 5.1 | 5.5 | 8.7 | 9.8 | |||
|
Percentage of dose excreted within the 24-h time period
|
6.3
|
6.8
|
10.8
|
12.0
| |||
↵ a Selected fecal samples with sufficient radioactivity from each subject were profiled for metabolites. The percentage of dose results were based on an extraction efficiency of 81%