TABLE 3

Induction of rat hepatic microsomal CYP3A activity by DPC 681

Gender
Number
Dose
6β-Hydroxylation
Fold Induction
mg/kg/day a pmol/min/mg b
Male 4 0 294±147 1.0
Male 4 200 1,166±118c 4.0
Female 4 0 33±11 1.0
Female
4
200
699±138c
21

  • ↵ a DPC 681 was dosed at 100 mg/kg, twice daily for 12 days

  • ↵ b Mean ± S.D. (n = 3)

  • ↵ c P < 0.01 compared with the respective vehicle control