TABLE 1

Pharmacokinetic parameters of antipyrine following a 20-mg/kg i.v. dose in mice and guinea pigs and the effect of pretreatment (2 h prior) with oral ABT on the antipyrine pharmacokinetics

ABT Dose	Sampling	Mouse					Guinea Pig
ABT Dose	Sampling			CL_p	AUC	t_1/2	CL_p	AUC	t_1/2
mg/kg		l/h/kg	μM·h	h	l/h/kg	μM·h	h
0	Terminal	1.35 ± 0.18	79.8 ± 10.5	0.5 ± 0.1
	Serial	1.67 ± 0.56	69.1 ± 21.6	0.9 ± 0.3	0.57 ± 0.16	198 ± 64	1.3 ± 0.5
50	Serial	0.08 ± 0.03	1463 ± 515	4.2 ± 2.2^*	0.09 ± 0.02	1214 ± 190	4.4 ± 1.1
100	Serial	0.08 ± 0.02	1366 ± 425	ND	0.03 ± 0	3300 ± 208	4.4 ± 0.5
150	Serial	0.10 ± 0.04	1112 ± 456	ND	0.03 ± 0.01	4553 ± 1450	5.0 ± 0.8

ND, not determined.
↵* Based on the last two time points only.