Cumulative biliary excretion of AA and AA metabolites after PB, DAS, OLT, or TSO pretreatment Experimental conditions are the same as those described for Fig. 1. Bile was collected over 90 min after administration of AA (1 mmol/kg i.v.). Values are means ± S.E.M.
AA-GLUC | AA-SULF | AA | AA-GSH | Total | |
|---|---|---|---|---|---|
| μmol/kg | |||||
| Control | 84.2±5.7 | 22.2±2.5 | 6.5±1.1 | 18.5±2.0 | 131±7.9 |
| PB | 37.8±8.1* | 8.4±1.3* | 16.4±4.8 | 63.2±6.2* | 126±7.1 |
| DAS | 16.3±0.9* | 6.4±0.3* | 4.0±0.6 | 11.2±3.3 | 38±3.1* |
| OLT | 16.4±1.7* | 4.5±0.2* | 5.8±0.7 | 16.5±3.8 | 43±4.1* |
|
TSO
|
18.6±5.8*
|
6.6±2.3*
|
4.9±0.9
|
6.2±2.5*
|
36±8.7*
|
↵* Significantly different from control (p ≤ 0.05)