Kinetic parameters for zonampanel uptake by hOATs
S2 hOAT1, S2 hOAT3, S2 hOAT4, and the mock were incubated in D-PBS containing various concentrations of [14C]zonampanel at 37°C for 5 min.
Km | Vmax | Vmax/Km | |
|---|---|---|---|
| μM | pmol/mg protein/min | μl/mg protein/min | |
| hOAT1 | 1.4 | 41.8 | 29.9 |
| hOAT3 | 7.7 | 44.0 | 5.7 |
| hOAT4 | 215 | 298 | 1.4 |