CYP3A Substrate | Enzyme Source | KI | kinact | kinact/KI | ||||||
---|---|---|---|---|---|---|---|---|---|---|
BG | DHB | BG | DHB | BG | DHB | |||||
μM | min−1 | μl/min/pmol | ||||||||
Testosterone | HIM | 28.6 | 2.5 | 0.34 | 0.40 | 12 | 160 | |||
CYP3A4 | 3.1 | 1.7 | 0.47 | 0.52 | 150 | 305 | ||||
Midazolam | HIM | 23.5 | 3.5 | 0.36 | 0.31 | 15 | 89 | |||
| CYP3A4 | 1.9 | 1.1 | 0.70 | 0.41 | 370 | 373 |