TABLE 2

High risk vs. low risk characteristics for moderate or large AUC_i/AUC ratios for metabolized drugs in the presence of inhibitor

High Risk of Large AUC_i/AUC Ratio	Low Risk of Large AUC_i/AUC Ratio
Metabolized by single enzyme^a	Metabolized by multiple enzymes^a
High I/K_i ratio^a	Low I/K_i ratio^a
High hepatic extraction^b	Low hepatic extraction^b
Low K_m (equal to, or greater than liver drug concentrations at therapeutic doses)^c	High K_m (much greater than liver drug concentrations at therapeutic doses)^a