TABLE 1

Comparison of ratios of intracellular N-demethyl-Ery to Ery in CMPF- and indoxyl sulfate-treated hepatoctyes Hepatocytes were incubated with Ery (2 μM) in the presence of various concentrations of CMPF and indoxyl sulfate. The intracellular amount of Ery and N-demethyl-Ery was measured in each group.

Concentration (μM)	CMPF^a	Indoxyl Sulfate^a
0	0.33 ± 0.02	0.33 ± 0.01
10	0.33 ± 0.01	N.D.
25	0.39 ± 0.03	0.34 ± 0.02
50	0.38 ± 0.02	0.28 ± 0.01^b
100	0.34 ± 0.03	0.27 ± 0.01^b
200	0.32 ± 0.02	0.24 ± 0.01^b
400	0.24 ± 0.01^b	0.23 ± 0.01^b
800	N.D.	0.22 ± 0.02^b

N.D., not determined.
↵ a Each value represents the mean ± S.E.M.
↵ b p < 0.05, significantly different from controls