Plasma concentration of CER and blood concentration of CsA after intravenous administration in rats
Plasma and blood concentrations of CER and CsA, respectively, were measured at 5 h after intravenous bolus injection and infusion of both compounds. All data are mean ± S.E. (n = 3-4).
Dose of CsA | Concentration of CsA | Concentration of CER |
|---|---|---|
| μM | nM | |
| 0 | 0 | 3.27 ± 0.12 |
| 1.16 μmol/kg bolus injection | 1.24 ± 0.02 | 4.56 ± 0.52 |
| → 0.175 mmol/h/kg infusion | ||
| 3.99 mmol/kg bolus injection | 3.02 ± 0.22 | 4.71 ± 0.29** |
| → 0.599 μmol/h/kg infusion |
|
|
↵** p < 0.01; a statistically significant difference from control by Dunnett's test.