TABLE 2

Inhibitory effects of CsA on the Oatp1a1-mediated uptake of [14C]CER

Uptake of [14C]CER (0.3 μM) was observed in rat Oatp1a1-transfected and vector transfected HEK293 cells.


Concentration of CsA

Oatp1a1-mediated uptake of [14C]CER
μM μl/min/mg protein
0 5.93 ± 1.01
0.1 3.66 ± 0.28**
1 3.65 ± 0.91
10
1.78 ± 0.63**
  • ** p < 0.01; a statistically significant difference from control by Dunnett's test.