Agent | IC50 |
---|---|
μM | |
Clomifene | 2.5 ± 0.6 |
Coumestrol | 0.48 ± 0.03 |
Diethylstilbestrol | 0.46 ± 0.05 |
Droloxifene | 0.79 ± 0.11 |
Estradiola | 0.29 ± 0.07 |
Estrone | 0.43 ± 0.09 |
Ethinyl estradiola | 0.57 ± 0.15 |
Fulvestrantb | 0.66 ± 0.10 |
Genistein | 0.34 ± 0.03 |
GW5638c | 57 ± 39 |
4-Hydroxytamoxifen | 0.45 ± 0.07 |
Levormeloxifene | 1.0 ± 0.1 |
Nafoxidine | 0.50 ± 0.14 |
Raloxifened | 0.0057 ± 0.0004 |
Tamoxifena | 2.2 ± 1.5 |
↵ b The inhibition demonstrated by fulvestrant topped out at 74% at concentrations above 1.5 μM. This could be due to solubility limitations. Data gathered at fulvestrant concentrations above 5 μM were not included in the calculation of IC50.
↵ c Estimated value. The highest concentration tested was 50 μM.
↵ d Combined value from previously reported values and additional measurements.