Kinetic parameters of nor-VER, D617, M1, M2, M3, and M4 metabolites in human CYP3A7 The values are expressed as mean of three and S.D.
Parameters | R-(+)- or S-(-)-VER | Metabolite | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| nor-VER | D617 | M1 | M2 | M3 | M4 | |||||||
| Km (μM) | R | 68.1 ± 7.7 | 53.2 ± 5.7 | 30.3 ± 1.5 | 58.6 ± 7.1 | 85.9 ± 11.0 | 60.0 ± 8.8 | |||||
| S | 55.6 ± 4.4 | 38.2 ± 3.9 | 22.0 ± 1.0 | 50.2 ± 4.0 | 51.8 ± 5.8 | 61.8 ± 7.0 | ||||||
| Vmax (pmol/min/mg) | R | 306 ± 19 | 112 ± 4 | 2.43 ± 0.03 | 1.42 ± 0.05 | 1.15 ± 0.05 | 2.21 ± 0.10 | |||||
| S | 605 ± 26 | 173 ± 5 | 3.14 ± 0.04 | 2.13 ± 0.05 | 0.94 ± 0.03 | 1.63 ± 0.06 | ||||||
| Ki (μM) | R | 482 ± 69 | NA | NA | NA | NA | NA | |||||
|
|
S
| 365 ± 34 | NA | NA | NA | NA | NA | |||||
NA, not applicable.