Amino acids (AA) reported to be involved in the active site structure, six putative substrate recognition sites (SRS) of CYP3A4, and their corresponding amino acids of CYP3A5 and CYP3A7
SRS Domain | CYP | StartingAA Position | Amino Acid |
|---|---|---|---|
| SRS-1 | 3A4 | 101 | V F T N R R P F G P V G F M K S A I S I A E D |
| 3A5 | V F T N R R S L G P V G F M K S A I S L A E D | ||
| 3A7 | V F T N R R P F G P V G F M K N A I S I A E D | ||
| SRS-2 | 3A4 | 204 | V E N T K K L L |
| 3A5 | V E S T K K L L | ||
| 3A7 | V E N T K K L L | ||
| SRS-3 | 3A4 | 238 | I C V F P R E |
| 3A5 | V S L F P K D | ||
| 3A7 | ITV F P R K | ||
| SRS-4 | 3A4 | 294 | E L V A Q S I I F I F A G Y E T T S S |
| 3A5 | E L A A Q S I I F I F A G Y E T T S S | ||
| 3A7 | E L M A Q S I I F I F A G Y E T T S S | ||
| SRS-5 | 3A4 | 368 | P I A M R L E R V |
| 3A5 | P V A I R L E R T | ||
| 3A7 | P V A M R L E R V | ||
| SRS-6 | 3A4 | 476 | K L S L G G L L Q P |
| 3A5 | K L D T Q G L L Q P | ||
|
| 3A7 |
| K L R F G G L L L T |
Bolded letters show different amino acids between CYP3A4 and CYP3A5 and also between CYP3A4 and CYP3A7. Underlined letters show different amino acids between CYP3A5 and CYP3A7.