TABLE 2

Relative contributions of HLM P450s and FMOs toward sulfoxidation of phorate, disulfoton, sulprofos, and methiocarb Values are the mean ± S.E.M. (n = 3).


Substrate

Sulfoxide Production

Percentage of Inhibition
nmol/mg
protein/min
Phorate
   HLM 2.34 ± 0.1
   HLM + 1-benzylimidazole 0.36 ± 0.0** 85
   HLM + 50°C/1 min 2.10 ± 0.1* 10
Disulfoton
   HLM 2.81 ± 0.1
   HLM + 1-benzylimidazole 0.30 ± 0.0** 89
   HLM + 50°C/1 min 2.56 ± 0.1* 9
Sulprofos
   HLM 0.51 ± 0.0
   HLM + 1-benzylimidazole 0.08 ± 0.0** 85
   HLM + 50°C/1 min 0.44 ± 0.0* 15
Methiocarb
   HLM 1.50 ± 0.0
   HLM + 1-benzylimidazole 0.19 ± 0.0** 87
   HLM + 50°C/1 min
1.37 ± 0.0*
9
  • Means significantly different from control are indicated by *P < 0.05 or **P < 0.01.