Sulfoxidation activity toward disulfoton with P450 and FMO isoforms Values are the mean ± S.E.M. (n = 3).
Km | Vmax | CLint | %TNR | |
|---|---|---|---|---|
| μM | nmol/nmol | μl/nmol | ||
| isoform/min | isoform/min | |||
| 1A2 | 19.4 ± 2.3 | 85.9 ± 3.1 | 4430 | 23.2 |
| 3A4 | 27.5 ± 2.4 | 55.6 ± 1.6 | 2020 | 25.4 |
| 2B6 | 11.2 ± 1.8 | 62.2 ± 2.7 | 5580 | 13.4 |
| 2C9*1 | 6.8 ± 1.6 | 14.7 ± 0.8 | 2160 | 24.1 |
| 2C9*2 | 16.1 ± 1.0 | 17.8 ± 0.3 | 1100 | N.D. |
| 2C18 | 10.3 ± 1.2 | 22.1 ± 0.9 | 2150 | 0.6 |
| 2C19 | 10.9 ± 2.0 | 58.2 ± 2.8 | 5340 | 11.8 |
| 2D6*1 | 72.7 ± 6.9 | 47.8 ± 2.0 | 660 | 0.8 |
| FMO1 | 7.3 ± 0.5 | 37.3 ± 0.7 | 5130 | 0.6 |
N.D., not determined.