TABLE 1
Pharmacokinetic parameters of PNU-96391 in Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after a single intravenous administration
Animals were administered intravenously a single bolus dose of PNU-96391 (mean ± S.D.; n = 4 in rats and dogs, n = 3 in monkeys). Plasma concentrations were determined by LC/MS-MS following protein precipitation, and pharmacokinetic parameters were calculated by the noncompartmental method. Data for rats and dogs are cited from Shobe et al. (2000).