TABLE 1

Pharmacokinetic parameters of PNU-96391 in Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after a single intravenous administration

Animals were administered intravenously a single bolus dose of PNU-96391 (mean ± S.D.; n = 4 in rats and dogs, n = 3 in monkeys). Plasma concentrations were determined by LC/MS-MS following protein precipitation, and pharmacokinetic parameters were calculated by the noncompartmental method. Data for rats and dogs are cited from Shobe et al. (2000).


Species

Weights

Dose

CLplasma

Vss

t1/2,z
kg mg/kg l/h/kg l/kg h
Rat 0.29 ± 0.0 5.4 ± 0.1 2.8 ± 0.4 1.5 ± 0.2 0.6 ± 0.1
Dog 13 ± 1 4.7 ± 0.1 2.2 ± 1.1 2.5 ± 1.5 1.1 ± 0.2
Monkey
6.1 ± 0.7
5.2 ± 0.2
2.0 ± 0.5
1.4 ± 0.3
0.8 ± 0.2