TABLE 2

Allometric scaling of the pharmacokinetic parameters of PNU-96391 across animal species and comparison of estimated and observed values in humans


Allometric Scaling

CLblood

Vss

t1/2,z
l/h/kg l/kg h
Allometric equation 2.28 × W0.910 1.56 × W1.10 0.722 × W0.154
Correlation coefficient (r2) 0.998 0.987 0.994
Data for humans
   Estimateda 1.6 2.4 1.4
   Observedb
0.43 ± 0.16
2.2 ± 0.6
3.4 ± 0.9
  • a The estimated values for humans calculated by allometric equation using a body weight of 70 kg

  • b The observed values obtained from the clinical studies (n = 39)