Compound | Fluorescent Probe in Intact Cells | Conventional Probe in Liver Microsomes | ||||
---|---|---|---|---|---|---|
IC50a | Type of Inhibitorb | IC50 | Type of Inhibitor | |||
Quinidine | 0.4 | potent | <0.3 | potent | ||
Ketoconazole | 1.4 | potent | 78.4 | poor | ||
Nifedipine | 7.7 | moderate | >30 | poor | ||
Amiodarone | 11.0 | moderate | 28.1 | moderate | ||
Verapamil | 12.6 | moderate | 18.0 | moderate | ||
Cyclosporine | 14.7 | moderate | 98.0 | poor | ||
Quinine | 18.1 | moderate | 11.8 | moderate | ||
Omeprazole | 18.5 | moderate | 53.2 | poor | ||
Ticlopidine | 25.2 | moderate | 28.4 | moderate | ||
Cimetidine | 33.2 | poor | 114 | poor | ||
Tranylcypromine | 192 | poor | 137 | poor | ||
Erythromycin | 219 | poor | >300 | noninhibitor | ||
Sulfaphenazole | 253 | poor | >300 | noninhibitor | ||
Quercetin | 263 | poor | 287 | poor | ||
Diethyldithiocarbamate | >300 | noninhibitor | >300 | noninhibitor | ||
Furafylline | >300 | noninhibitor | >300 | noninhibitor | ||
Lovastatin | >300 | noninhibitor | >300 | noninhibitor |