Clearance in vivo and calculated hepatic clearance values from CLint (Vmax/Km measurements or, for diclofenac and fluvastatin, also Vmax/Km + Cmax; values in parentheses) The predicted hepatic CL values for fluvastatin are the sum of low and high affinity enzyme kinetic terms. Values are ml/min/70 kg. The equations for hepatic CLint and hepatic clearance are shown below.
Clearance | Protein Binding | Diclofenac | Tolbutamide | Ibuprofen | Fluvastatin | |||
|---|---|---|---|---|---|---|---|---|
| ml/min | ||||||||
| Blood CL in vivoa | 424—667b | 31c | 64—127b | 329—648b | ||||
| Predicted CLhepatic | No protein binding included | 1340 | 120 | 718 | 1227 | |||
| (1240) | (1061) | |||||||
| Plasma protein binding included | 96 | 2.6 | 15 | 175 | ||||
| (32) | (84) | |||||||
| Plasma and microsomal protein binding included | 112 | 2.6 | 15 | 272 | ||||
|
|
| (38) |
|
| (134) | |||
Equations: CLint = Vmax · 1500 g liver weight · 45 mg microsomal protein/g liver/Km; CLhepatic = Q · fu · CLint/(Q + fu · CLint).
↵ a Blood clearance was calculated from published plasma clearance values. The blood vs. plasma ratio is 0.55 for diclofenac, tolbutamide, and ibuprofen (Obach. 1999) and 1.8 for fluvastatin (Cennernäs and Fager, 1997)