TABLE 4

The I/Ki ratio for the CYP2C9 substrates The Cmax values were used as inhibitor concentrations. The ratios are expressed both in terms of total and unbound concentrations (values from Tables 1 and 2).


Inhibitor

I/Ki,total

Iu/Ki,u
Tolbutamide 2.8 0.056
Ibuprofen 3.8 0.032
Fluvastatin 5 0.17
Diclofenac
0.67
0.023