Substrate | Inhibitor | Eq. 1a ^{a} | Eq. 1b ^{b} | Eq. 3or 4^{c} | Observed AUC-Ratio (90% CI) |
---|---|---|---|---|---|
Diclofenac | Tolbutamide | 3.8 | 1.0 | 1.1 | 0.93 (0.7—1.24) |
Diclofenac | Ibuprofen | 2.2 | 1.0 | 1.1 | 0.99 (0.77—1.26) |
Diclofenac | Fluvastatin | 6.3 | 2.0 | 1.7 | 1.07 (0.82—1.41) |
Tolbutamide | Diclofenac | 1.7 | 1.6 | 1.0 | 1.01 (0.85—1.20) |
Ibuprofen | Diclofenac | 1.6 | 1.4 | 1.0 | 1.03 (0.84—1.26) |
Fluvastatin | Diclofenac | 2.6 | 1.0 | 1.0 | 1.08 (0.81—1.45) |
CI, confidence interval.
↵ a Equation 1a: AUC ratio = v(I)/v(control) = 1/ (1 + I/K_{i}), I = C_{max} total; K_{i} total
↵ b Equation 1b. The free fractions for the inhibitor (I_{u}) and K_{i} (K_{i,u}) are used
↵ c Equation 3: AUC ratio = 1/((f_{m}/1 + I_{u}/K_{i}) + 1 — f_{m}) (fluvastatin); eq. 4: AUC ratio = 1/(f_{h}·f_{m}(1/1 + I_{u}/K_{i}) + (1 — f_{h}·f_{m})) (diclofenac, tolbutamide, ibuprofen)