TABLE 1

Fixed parameters for physiological model of DIM in mice

Tissue
Blood Flowa
Weight or Volumeb
Tissue-Plasma Partition Coefficient
ml/h g or ml
Lung 839 0.22 3.11
Liver 135 1.65 7.84
Kidney 76.0 0.50 3.40
Heart 55.0 0.15 2.87
Brain 28.0 0.50 1.21
Remainder 545 25.8 —c
Arterial Pool — 0.24 —
Venous Pool
—
0.94
—

  • ↵ a Values for tissues were obtained from Brown et al. (1997), and blood flow to remainder was calculated as the difference between cardiac output (see value for lung) and the sum of blood flows to the sampled tissues

  • ↵ b Values for tissues were obtained from Brown et al. (1997), and remainder weight was calculated as the difference between total body weight (30 g) and the sum of the other tissue weights

  • ↵ c -, not applicable