TABLE 2

Apparent IC50 values of BNPP, DFP, THU, and TPI on 5′-DFCR, 5′-DFUR, and 5-FU formations Capecitabine (0.05—3 mM) was incubated with the combination of microsomes (0.5 mg/ml) and cytosol (2.5 mg/ml) obtained from BD Gentest. BNPP, DFP, THU, and TPI concentrations ranged from 0.1 to 10 μM, 0.01 to 1 μM, 0.04 to 4 μM, and 5 to 100 nM, respectively.


Inhibitor

5′-DFCR Formation

5′-DFUR Formation

5-FU Formation
nM
BNPP 740
DFP 154
THU 55
TPI


10