Correlation of 5-hydroxytryptophol glucuronidation with UGT1A6 protein content and marker activities for the major hepatic UGT isoforms measured by using the same set of human liver microsomes Values represent the Spearman rank order correlation coefficient (Rs), P value, and number of livers (n) for the indicated comparisons.
5-Hydroxytryptophol Glucuronidation vs. | |||||
|---|---|---|---|---|---|
| Rs | P value | n | |||
| UGT1A6 protein | 0.85 | <0.001 | 52 | ||
| Serotonin glucuronidation (UGT1A6) | 0.83 | <0.001 | 54 | ||
| 4-Nitrophenol glucuronidation (UGT1A6) | 0.74 | <0.001 | 54 | ||
| Estradiol-3-glucuronidation (UGT1A1) | 0.67 | <0.001 | 54 | ||
| Trifluoperazine glucuronidation (UGT1A4) | 0.62 | <0.001 | 54 | ||
| Propofol glucuronidation (UGT1A9) | 0.50 | <0.001 | 54 | ||
| Acetaminophen glucuronidation (UGT1A) | 0.39 | 0.042 | 27 | ||
| AZT glucuronidation (UGT2B7) | 0.22 | 0.12 | 54 | ||
| S-Oxazepam glucuronidation (UGT2B15) | 0.33 | 0.015 | 54 | ||