Agent | F | Species | PXR Activation | ||
---|---|---|---|---|---|
hPXR | mPXR | ||||
Dexamethasone | 78% | Human | 0 | ++ | |
Nelfinavir | ND | 0 | 0 | ||
Nifedipine | 50% | Human | ++ | + | |
PCN | ND | 0 | +++ | ||
Rifampin | 76% | Rat | +++ | 0/+ | |
St. John's wort | ND | ++ | ND | ||
Tamoxifen | >95% | Human | + | 0 |
F, oral bioavailability; hPXR, human PXR; mPXR, mouse PXR; 0, no activity; +, some activity; ++, moderate activity; +++, strong activity; ND, no data.