TABLE 1

Percentage recoveries of radioactivity in bile and urine following intravenous administration of [14C]MRL-I or [14C]MRL-II to male Sprague-Dawley rats at 1 and 0.5 mg/kg, respectively

Samplesa
MRL-I
MRL-II
Bile 102 ± 10.4b 62 ± 2b
Urine 8.2 ± 2.7 29 ± 2
Total
110 ± 13.1
91 ± 0.1

  • ↵ a Bile and urines samples were collected over a 72-h period.

  • ↵ b Mean ± standard deviation values are from n = 4 or 3 male rats for MRL-I and MRL-II, respectively.