TABLE 3

Comparison of hepatic expression of drug-metabolizing enzymes and xenobiotic transporters in obese Zucker and Sprague-Dawley rats

Gene
Expression in Zucker Rats (% Decrease Compared with Sprague-Dawley Rats)a
Mean
Standard Deviation
CYP3A1 * 29 0.055
CYP2C11 * 44 0.071
UGT1A1 * 33 0.07
UGT1A6 * 52 0.042
UGT2B1 * 63 0.098
Mrp2 * 51 0.024
Mrp3 10 0.081
Oatp2 * 80 0.029
GSTA2 * 72 0.039
QR *
28
0.094

  • ↵ a n = 4 or 3 for the obese Zucker and the Sprague-Dawley rats, respectively. Three determinations were performed for each animal.

  • ↵* Significantly different from values in Sprague-Dawley rats (p < 0.05, Student's t test).