Pharmacokinetic parameters of E3040S after intravenous infusion in Bcrp1(−/−) and wild-type mice
Results are mean ± S.E. (n = 6).
Wild Type | Bcrp1(−/−) | |
|---|---|---|
| Cp (μM) | 7.01 ± 0.93 | 8.84 ± 1.23 |
| Vurine (nmol/min/kg) | 46.2 ± 6.7 | 23.7 ± 4.2* |
| CLtotal (ml/min/kg) | 11.7 ± 1.1 | 9.28 ± 1.21 |
| CLrenal,p (ml/min/kg) | 6.55 ± 0.52 | 2.74 ± 0.41* |
| CLrenal,k (ml/min/kg) | 2.35 ± 0.13 | 0.59 ± 0.19** |
|
K
p,kidney
| 2.79 ± 0.28 | 6.62 ± 1.30* |
Cp, plasma concentrations at 90 min; Vurine, urinary excretion rate from 60 to 90 min; CLtotal, total clearance; CLrenal,p, renal clearance with respect to circulating plasma; CLrenal,k, renal clearance with respect to the kidney concentration; Kp,kidney, kidney-to-plasma concentration ratio.
*p < 0.05, **p < 0.01, significantly different from wild-type mice.