TABLE 2

Pharmacokinetic parameters of E3040S after intravenous infusion in Bcrp1(−/−) and wild-type mice

Results are mean ± S.E. (n = 6).




Wild Type

Bcrp1(−/−)
Cp (μM) 7.01 ± 0.93 8.84 ± 1.23
Vurine (nmol/min/kg) 46.2 ± 6.7 23.7 ± 4.2*
CLtotal (ml/min/kg) 11.7 ± 1.1 9.28 ± 1.21
CLrenal,p (ml/min/kg) 6.55 ± 0.52 2.74 ± 0.41*
CLrenal,k (ml/min/kg) 2.35 ± 0.13 0.59 ± 0.19**
K p,kidney
2.79 ± 0.28
6.62 ± 1.30*
  • Cp, plasma concentrations at 90 min; Vurine, urinary excretion rate from 60 to 90 min; CLtotal, total clearance; CLrenal,p, renal clearance with respect to circulating plasma; CLrenal,k, renal clearance with respect to the kidney concentration; Kp,kidney, kidney-to-plasma concentration ratio.

    *p < 0.05, **p < 0.01, significantly different from wild-type mice.