TABLE 3

Gene array analysis of comparative expression of biotransformation genes in adult and fetal human liver and nasal mucosa RNA samples were from the liver (FL) and nasal mucosa (FN) of a white female fetus at the gestational age of 115 days (#16029), autopsy liver tissue from a 27-year-old Asian male (AL), and nasal mucosa (AN) from pooled biopsy samples from three male Asian subjects (32, 52, and 66 years old, respectively). Only genes with apparently selective expression in the nasal mucosa are shown. The absolute call was present, unless indicated otherwise.


Probe Set

Gene

Accession No.

Signal Intensity
FN
FL
AN
AL
arbitrary units
36686_at ALDH6 U07919 1050 129a 1490 248a
40685_at ALDH7 U10868 2640 380a 2800 708a
40071_at CYP1B1 U03688 1810 163a 4360 270a
859_at CYP1B1 U03688 1260 98a 3150 95a
1517_at CYP2F1 J02906 5730b 635a 3070a 1530a
1667_s_at CYP4B1 J02871 7370 1700a 5120 2850a
31806_at FMO1 M64082 625 59a 512 99a
33396_at GSTP1 U12472 19,600 8570 14,500 6020
829_s_at GSTP1 U21689 26,100 12,000 17,700 5410a
31646_at
UGT2A
AJ006054
2110
58a
1510
171a
  • a Absolute call, absent

  • b Absolute call, marginal