TABLE 2

Effect of cell concentration on triazolam, diazepam, and clonazepam in vitro CLint in rat hepatocytes

Values are mean ± S.D. (n = 4). CLint is expressed as μl/min/106 cells.

Cell Density (× 106 Cells/ml)
Triazolam
Diazepam
Clonazepam
0.5 170 ± 59 160 ± 14 17 ± 1.9
1 150 ± 42
2 130 ± 33
4
88 ± 22a
99 ± 14a
11 ± 0.5a

  • ↵ a Significantly different from the lowest cell density (p < 0.05, Dunnett's test for triazolam and two-way ANOVA for diazepam and clonazepam).