TABLE 5

Cytochrome P450 activity (nmol/min) with respect to triazolam 4-hydroxylation and clonazepam 3-hydroxylation in rat microsomes

Values are mean ± S.D. (n = 4).

Time (min)	Triazolam							Clonazepam
Time (min)		0.5 mg/ml	1 mg/ml	2 mg/ml	5 mg/ml	0.5 mg/ml	5 mg/ml
0	0.082 ± 0.027 (100)^a	0.13 ± 0.035 (100)	0.16 ± 0.031 (100)	0.18 ± 0.021 (100)	0.041 ± 0.015 (100)	0.10 ± 0.031 (100)
30	0.068 ± 0.021 (83)	0.083 ± 0.018^b (66)	0.12 ± 0.029^b (74)	0.085 ± 0.024^b (47)	0.034 ± 0.013 (83)	0.048 ± 0.0084^b (46)
60	0.047 ± 0.014^b (58)	0.069 ± 0.016^b (55)	0.071 ± 0.013^b (44)	0.014 ± 0.0077^b (8)	0.027 ± 0.011 (65)

↵ a Numbers in parentheses represent a percentage of the time = 0 value.
↵ b Significantly different from the corresponding time = 0 value (p < 0.05, Dunnett's test).