Site and Type of Metabolic Reaction  Compound Name and Presence in Matrix  

Chemical Structure  R=CH_{3}  R=H  
Imatinib (parent drug)  CGP74588 (main metabolite)  
P, 17.7 (70)  P, 2.4 (9.5)  
U, 5.0; F, 23  U, <1.8; F, <11  
M21.0 (glucuronide)  M20.0a (glucuronide)  
P, 1.0 (4.0)  P, <0.4 (<1.6)  
U, ≤0.4  U, ≤0.2  
CGP72383  
P, 0.29 (1.1)  
U, ≤0.3  
AFN911  
P, <0.22 (<0.9)  
U, ≤0.4; F, ≤2  
CGP71422  
P, <0.21 (<0.8)  
U, <0.3; F, ≤0.3  
APG050  APG049  
P, 0.32 (1.2)  P, 0.11 (0.4)  
U, ≤1.5; F, <0.3  U, 0.1; F, 1.6  
M23.7 (glucuronide)  
U, ≤0.3  
M29.6  M28.8  
P, <0.21 (<0.8)  U, <0.1  
U, <0.3; F, ≤1  
M27.6 (glucuronide)  M25.6 (glucuronide)  
U, ≤0.3  U, ≤0.5  
M42.2  
 U, 0.1; F, 1.3 
